DFG Research Training Group "TJ-Train" (GRK 2318)
 Tight junctions and their proteins
Molecular features and actions in health and disease
                  Publications of the doctoral students

Back            Updated 21.06.2024
 
Project A1

  • Wuttke M, König E, Katsara MA, Kirsten H, Khomeijani Farahani S, Teumer A, Li Y, Lang M, Göçmen B, Pattaro C, Günzel D, Köttgen A, Fuchsberger C (2023) Imputation-powered whole-exome analysis identifies genes associated with kidney function and disease in the UK Biobank. Nat. Commun. 14: 1287 (16 pages), doi: 10.1038/s41467-023-36864-8 (IF 14.7)

  • Beier LS*, Waldow A* (*shared first authorship), Khomeijani Farahani S, Mannweiler R, Vidal-Y-Sy S, Brandner JM, Piontek J°, Günzel D° (°shared last authorship) (2022) Claudin targeting as an effective tool for directed barrier modulation of the viable epidermis. Ann. NY Acad. Sci. 1517(1): 251-265, doi: 10.1111/nyas.14879 (IF 5.2)

  • Mannweiler R, Bergmann S, Vidal-Y-Sy S, Brandner JM, Günzel D (2021) Direct assessment of individual skin barrier components by electrical impedance spectroscopy. Allergy 76(10): 3094-3106 (13 pages). doi: 10.1111/all.14851, Supplement PDF (IF 14.7)

  • Alzahrani AS, Hussein M, Alswailem M, Mouna A, Albalawi L, Moria Y, Jabbar MA, Shi Y, Günzel D*, Dasouki M* (*equally contributing) (2021) A novel claudin-10 mutation with a unique mechanism in two unrelated families with HELIX syndrome. Kidney Int. 100(2): 415-429, doi: 10.1016/j.kint.2021.02.023, Supplement (IF 19.0)

Project A2

  • Martínez-Perafán F, Fromm A, van der Veen RE, Waldow A, Lehmann M, Krug SM, Günzel D, Rosenthal R, Fromm M, Piontek J (2025) Effect of claudin-1 or -3 expression on cation and water channel properties of claudin-2. BBA - Mol. Cell Res. 1872(4): 119930 (17 pages). doi: 10.1016/j.bbamcr.2025.119930 (°IF 3.7)

  • Nagarajan SK, Weber J, Roderer D, Piontek J (2024) C. perfringens enterotoxin-claudin pore complex: Models for structure, mechanism of pore assembly and cation permeability. Comp. Struct. Biotechnol. J.  27: 287-306. doi: 10.1016/j.csbj.2024.11.048 (IF 4.1)

  • Waldow A*, Beier LS* (*shared first authorship), Arndt J, Schallenberg S, Vollbrecht C, Bischoff P, Farrera-Sal M, Loch FN, Bojarski C, Schumann M, Winkler L, Kamphues C, Ehlen L°, Piontek J° (°shared last authorship) (2023) cCPE fusion proteins as molecular probes to detect claudins and tight junction dysregulation in gastrointestinal cell lines, tissue explants and patient-derived organoids. Pharmaceutics 15(7): 1980 (23 pages). doi: 10.3390/pharmaceutics15071980 (IF 4.9)

  • Beier LS*, Waldow A* (*shared first authorship), Khomeijani Farahani S, Mannweiler R, Vidal-Y-Sy S, Brandner JM, Piontek J°, Günzel D° (°shared last authorship) (2022) Claudin targeting as an effective tool for directed barrier modulation of the viable epidermis. Ann. NY Acad. Sci. 1517(1): 251-265, doi: 10.1111/nyas.14879 (IF 5.2)

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  • Beier LS, Rossa J, Woodhouse S, Bergmann S, Kramer HB, Protze J, Eichner M, Piontek A, Vidal-y-Sy S, Brandner JM, Krause G, Zitzmann N, Piontek J (2019) Use of modified Clostridium perfringens enterotoxin fragments for claudin targeting in liver and skin cells. Int. J. Mol. Sci. 20(19): 4774 (20 pages) [PubMed] [WebPage] [PDF] (IF 4.6) [Supplement PDF]

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  • Piontek A, Eichner M, Zwanziger D, Beier LS, Protze J, Walter W, Theurer S, Schmid KW, Führer-Sakel D, Piontek J*, Krause G* (*shared last authorship) (2020) Targeting claudin-overexpressing thyroid and lung cancer by modified Clostridium perfringens enterotoxin. Mol. Oncol. 14(2): 261-276 [PubMed] [WebPage] [PDF] (IF 6.6)

    • Book chapter

  • Beier LS, Piontek J, Piontek A, Protze J, Kobelt D, Walther W (2022) Claudin-targeted suicide gene therapy for claudin-overexpressing tumor cells by using modified Clostridium perfringens enterotoxin (CPE). In: Walter W (ed), Gene therapy of cancer. Methods Mol. Biol. 2521: 173-188. doi: 10.1007/978-1-0716-2441-8_9

Project A3

  • Martínez-Perafán F, Fromm A, van der Veen RE, Waldow A, Lehmann M, Krug SM, Günzel D, Rosenthal R, Fromm M, Piontek J (2025) Effect of claudin-1 or -3 expression on cation and water channel properties of claudin-2. BBA - Mol. Cell Res. 1872(4): 119930 (17 pages). doi: 10.1016/j.bbamcr.2025.119930 (°IF 3.7)

  • Ayala-Torres C, Krug SM, Rosenthal R*, Fromm M* (*shared last authorship) (2021) Angulin-1 (LSR) affects paracellular water transport, however only in tight epithelial cells. Int. J. Mol. Sci. 22: 7827 (25 pages). doi: 10.3390/ijms22157827 (IF 6.2)

  • Ayala-Torres C, Krug SM, Schulzke JD, Rosenthal R*, Fromm M* (*shared last authorship) (2019) Tricellulin effect on paracellular water transport. Int. J. Mol. Sci. 20 (22): 5700 (15 pages) [PubMed] [WebPage] [PDF] (IF 4.6)

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  • Rosenthal R, Günzel D, Piontek J, Krug SM, Ayala-Torres C, Hempel C, Theune D, Fromm M (2020) Claudin-15 forms a water channel through the tight junction with distinct function compared to claudin-2. Acta Physiol. 228(1): e13334 (15 pages) [PubMed] [WebPage] [PDF]  (IF 6.3)


Project A4

  • Martínez-Perafán F, Fromm A, van der Veen RE, Waldow A, Lehmann M, Krug SM, Günzel D, Rosenthal R, Fromm M, Piontek J (2025) Effect of claudin-1 or -3 expression on cation and water channel properties of claudin-2. BBA - Mol. Cell Res. 1872(4): 119930 (17 pages). doi: 10.1016/j.bbamcr.2025.119930 (°IF 3.7)

  • Schmied C, Ebner M, Samsó P, van der Veen R, Haucke V, Lehmann M (2024) OrgaMapper: a robust and easy-to-use workflow for analyzing organelle positioning. BMC Biol. 22(1): 220. doi: 10.1186/s12915-024-02015-8 (IF 4.5)

  • van der Veen RE, Piontek J, Bieck M, Saiti A, Gonschior H, Lehmann M (2024) Claudin-4 polymerizes after a small extracellular claudin-3-like substitution. J. Biol. Chem. 300(10): 107693 (14 pages). doi: 10.1016/j.jbc.2024.107693

    • (IF 3.9)

  • Mukenhirn M, Wang CH, Guyomar T, Bovyn MJ, Staddon MF, van der Veen RE, Maraspini R, Lu L, Martin-Lemaitre C, Sano M, Lehmann M, Hiraiwa T, Riveline D, Honigmann A (2024) Tight junctions control lumen morphology via hydrostatic pressure and junctional tension. Dev. Cell 59(21): 2866-2881.e8. doi: 10.1016/j.devcel.2024.07.016 (IF 8.7)

  • Gonschior H, Schmied C, van der Veen RE, Eichhorst J, Himmerkus N, Piontek J, Günzel D, Bleich M, Furuse M, Haucke V, Lehmann M (2022) Nanoscale segregation of channel and barrier claudins enables paracellular ion flux. Nat. Commun. 13(1): 4985 (20 pages). doi: 10.1038/s41467-022-32533-4, Supplement (IF 16.6)

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  • Mecklenburg N*, Kowalczyk I*, Witte F* (*shared first authorship), Goerne J, Laier A, Mamo TM, Gonschior H, Lehmann M, Richter M, Sporbert A, Purfuerst B, Hübner N, Hammes A (2021) Identification of novel disease relevant modulators of the SHH pathway in the developing brain. Development 148(17): (17 pages) doi: 10.1242/dev.199307 (IF 6.9) #

  • Gonschior H, Haucke V, Lehmann M (2020) Super-resolution imaging of tight and adherens junctions: Challenges and open questions. Int. J. Mol. Sci. 21(3): 744 (15 pages) [PubMed] [WebPage] [PDF]  (Review) (IF 5.9)

  • Gonschior H, Schmied C, Van der Veen R, Eichhorst J, Himmerkus N, Piontek J, Günzel D, Bleich M, Furuse M, Haucke V, Lehmann M (2022) Nanoscale segregation of channel and barrier claudins enables paracellular ion flux. Nat. Commun. 13(1): 4985 (20 pages). doi: 10.1038/s41467-022-32533-4, Supplement (°IF 17.7)

Project B1

  • Mecklenburg N*, Kowalczyk I*, Witte F* (*shared first authorship), Goerne J, Laier A, Mamo TM, Gonschior H, Lehmann M, Richter M, Sporbert A, Purfuerst B, Hübner N, Hammes A (2021) Identification of novel disease relevant modulators of the SHH pathway in the developing brain. Development (19.07.2021 accepted for publication) (IF 6.9) #

  • Kowalczyk I, Lee C, Schuster E, Hoeren J, Trivigno V, Riedel L, Görne J, Wallingford JB, Hammes A, Feistel K (2021) Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds. Development 148(2): dev195008. doi: 10.1242/dev.195008 (IF 6.9)

Project B2

  • Cardoso-Silva D*, Delbue D* (*shared first authorship), Itzlinger A, Moerkens R, Withoff S, Branchi F, Schumann M (2019) Intestinal barrier function in gluten-related disorders. Nutrients 11(10): 2325 (19 pages) [PubMed] [WebPage] [PDF]  (Review) (IF 4.5) #

  • Delbue D, Lebenheim L, Cardoso-Silva D, Dony V, Krug SM, Richter JF, Manna S, Muñoz M, Wolk K, Heldt C, Heimesaat MM, Sabat R, Siegmund B, Schumann M (2021) Reprogramming intestinal epithelial cell polarity by interleukin-22. Front. Med. (Lausanne) 8: 656047. doi: 10.3389/fmed.2021.656047 (IF 5.1) #

  • Delbue D, Cardoso-Silva D, Branchi F, Itzlinger A, Letizia M, Siegmund B, Schumann M (2019) Celiac disease monocytes induce a barrier defect in intestinal epithelial cells. Int. J. Mol. Sci. 20(22): 5597 (12 pages) [PubMed] [WebPage] [PDF] (IF 4.6) #

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Project B3

  • Franken GAC*, Seker M* (*shared first authorship), Bos C, Siemons LAH, van der Eerden BCJ, Christ A, Hoenderop JGJ, Bindels RJM, Müller D, Breiderhoff T, de Baaij JHF (2021) Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects. Sci. Rep. 11(1): 8217. doi: 10.1038/s41598-021-87548-6. (IF 5.0)

  • Seker M, Fernandez-Rodriguez C, Martinez-Cruz LA, Müller D (2019) Mouse models of human claudin-associated disorders: benefits and limitations. Int. J. Mol. Sci. 20(21): 5504 (19 pages) [PubMed] [WebPage] [PDF]  (Review) (IF 4.6)

Project B4

  • Tsamo Tetou A, Günzel D (2024) The role of claudins in renal transepithelial transport and kidney disease. Curr. Opin. Nephrol. Hypertens. 33(5): 535-542 (8 pages), doi: 10.1097/mnh.0000000000001003 (°IF 2.4) (Review)

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  • Leiz J*, Hinze C* (*shared first authorship), Boltengagen A, Braeuning C, Kocks C, Rajewsky N, Schmidt-Ott KM (2021) Nuclei isolation from adult mouse kidney for single-nucleus RNA-sequencing. J. Vis. Exp. 175 doi: 10.3791/62901 (IF 1.4)

  • Leiz J, Schmidt-Ott K (2020) Claudins in the renal collecting duct. Int. J. Mol. Sci. 21(1): 221 (11 pages) (Review) [PubMed] [WebPage] [PDF] (IF 5.9)

Project C1

  • Hader H, Hering NA, Schulzke JD, Bücker R, Rosenthal R (2023) Myrrh protects against IL-13-induced epithelial barrier breakdown in HT-29/B6 cells. Front. Pharmacol. 14: 1301800 (11 pages). doi: 10.3389/fphar.2023.1301800 (IF 4.4)

  • Schneemann M, Heils L, Moos V, Weiß F, Krug SM, Weiner J, Beule D, Gerhard R, Schulzke JD, Bücker R (2023) A colonic organoid model challenged with the large toxins of Clostridioides difficile TcdA and TcdB exhibit deregulated tight junction proteins. Toxins 15: 643 (19 pages). doi: 10.3390/toxins15110643 (IF 3.9)

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  • Heils L, Schneemann M, Gerhard R, Schulzke JD, Bücker R (2023) CDT of Clostridioides difficile induces MLC-dependent intestinal barrier dysfunction in HT-29/B6 epithelial cell monolayers. Toxins (Basel) 15(1): 54 (15 pages). doi: 10.3390/toxins15010054 (°IF 4.2)

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  • Kaak JL, Lobo de Sá FD, Turner JR, Schulzke JD, Bücker R (2022) Unraveling the intestinal epithelial barrier in cyanotoxin microcystin-treated Caco-2 cell monolayers. Ann. NY Acad. Sci. 1516(1): 188-196, doi: 10.1111/nyas.14870 (IF 5.2)

  • Weiß F, Holthaus D, Kraft M, Klotz C, Schneemann M, Schulzke JD, Krug SM (2022) Human duodenal organoid derived monolayers serve as a suitable barrier model for duodenal tissue. Ann. NY Acad. Sci. 1515(1): 155-167, doi: 10.111/nyas.14804 (IF 5.2)

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  • Nattramilarasu PK, Lobo de Sá FD, Schulzke JD, Bücker R (2021) Immune-mediated aggravation of the Campylobacter concisus-induced epithelial barrier dysfunction. Int. J. Mol. Sci. 22(4): 2043 (23 pages). doi: 10.3390/ijms22042043, Supplement PDF (IF 6.2)

  • Nattramilarasu PK, Bücker R, Lobo de Sá FD, Fromm A, Nagel O, Lee IM, Butkevych E, Mousavi S, Genger C, Kløve S, Heimesaat MM, Bereswill S, Schweiger MR, Nielsen HL, Troeger H, Schulzke JD (2020) Campylobacter concisus impairs sodium absorption in colonic epithelium via ENaC dysfunction and claudin-8 disruption. Int. J. Mol. Sci. 21(2): e373 (23 pages) [PubMed] [WebPage] [PDF] [Supplements] (IF 5.9)

  • Butkevych E, Lobo De Sá FD, Nattramilarasu PK, Bücker R (2020) Contribution of epithelial apoptosis and subepithelial immune responses in Campylobacter jejuni-induced barrier disruption Front. Microbiol. 11: 344 (14 pages) [PubMed] [WebPage] [PDF] (IF 5.6)

  • Lobo de Sá FD, Heimesaat MM, Bereswill S, Nattramilarasu PK, Schulzke JD, Bücker R (2021) Resveratrol prevents Campylobacter jejuni-Induced leaky gut by restoring occludin and claudin-5 in the paracellular leak pathway. Front. Pharmacol. 12: 640572. doi: 10.3389/fphar.2021.640572 (IF 6.0)

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  • Lobo de Sá FD, Butkevych E, Nattramilarasu PK, Fromm A, Mousavi S, Moos V, Golz JC, Stingl K, Kittler S, Seinige D, Kehrenberg C, Heimesaat MM, Bereswill S, Schulzke JD*, Bücker R (*corresponding) (2019) Curcumin mitigates immune-induced epithelial barrier dysfunction by Campylobacter jejuni. Int. J. Mol. Sci. 20(19): 4830 (19 pages) [Pubmed] [WebPage] [PDF] (IF 4.6)

  • Schulz E, Schumann M, Schneemann M, Dony V, Fromm A, Nagel O, Schulzke JD, Bücker R (2021) Escherichia coli alpha-hemolysin HlyA induces host cell polarity changes, epithelial barrier dysfunction and cell detachment in human colon carcinoma  Caco-2 cell model via PTEN-dependent dysregulation of cell junctions. Toxins 13(8): 520 (22 pages). doi: 10.3390/toxins13080520. (IF 5.1) #

Project C2

  • Voges L, Weiß F, Branco AT, Fromm M, Krug SM (2024) Expression and localization profiles of tight junction proteins in immune cells depend on their activation status. Int. J. Mol. Sci. 25(9): 4861 (18 pages), doi: 10.3390/ijms25094861 (IF 4.9)

  • Weiß F, Czichos C, Knobe L, Voges L, Bojarski C, Michel G, Fromm M, Krug SM (2022) MarvelD3 is upregulated in ulcerative colitis and has attenuating effects during colitis indirectly stabilizing the intestinal barrier. Cells 11: 1551 (16 pages) doi: 10.3390/cells11091541 (IF 6.0)

  • Hu JCE, Weiß F, Bojarski C, Branchi F, Schulzke JD, Fromm M, Krug SM (2021) Expression of tricellular tight junction proteins and the paracellular macromolecule barrier are recovered in remission of ulcerative colitis. BMC Gastroenterology 21(1): 141, doi: 10.1186/s12876-021-01723-7 (IF 2.9) 

  • Hu JCE, Bojarski C, Branchi F, Fromm M, Krug SM (2020) Leptin downregulates angulin-1 in active Crohn's disease via STAT3. Int. J. Mol. Sci. 21(21): 7824 (17 pages) [PubMed] [WebPage] [PDF] [Supplement] (IF 5.9)

Project C3

  • Delbue D, Lebenheim L, Cardoso-Silva D, Dony V, Krug SM, Richter JF, Manna S, Muñoz M, Wolk K, Heldt C, Heimesaat MM, Sabat R, Siegmund B, Schumann M (2021) Reprogramming intestinal epithelial cell polarity by interleukin-22. Front. Med. (Lausanne) 8: 656047. doi: 10.3389/fmed.2021.656047 (IF 5.1) #

  • Delbue D, Cardoso-Silva D, Branchi F, Itzlinger A, Letizia M, Siegmund B, Schumann M (2019) Celiac disease monocytes induce a barrier defect in intestinal epithelial cells. Int. J. Mol. Sci. 20(22): 5597 (12 pages) [PubMed] [WebPage] [PDF] (IF 4.6) #

  • Cardoso-Silva D*, Delbue D* (*shared first authorship), Itzlinger A, Moerkens R, Withoff S, Branchi F, Schumann M (2019) Intestinal barrier function in gluten-related disorders. Nutrients 11(10): 2325 (19 pages) [PubMed] [WebPage] [PDF] (Review) (IF 4.5) #

  • Schulz E, Schumann M, Schneemann M, Dony V, Fromm A, Nagel O, Schulzke JD, Bücker R (2021) Escherichia coli alpha-hemolysin HlyA induces host cell polarity changes, epithelial barrier dysfunction and cell detachment in human colon carcinoma Caco-2 cell model via PTEN-dependent dysregulation of cell junctions. Toxins 13(8): 520 (22 pages). doi: 10.3390/toxins13080520 (IF 5.1) #

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Project C4

  • Masete KV, Massarani AS, Schulzke JD, Epple HJ*, Hering NA* (*shared last authorship) (2025) Tumour necrosis factor-α induces macromolecule translocation in HIV-derived duodenal organoids. Front Immunol. 16: 1563702 (12 pages). doi: 10.3389/fimmu.2025.1563702 (°IF 5.9)

  • Masete KV, Günzel D, Schulzke JD, Epple HJ*, Hering NA* (*shared last authorship) (2025) Matrix-free human 2D organoids recapitulate duodenal barrier and transport properties. BMC Biol. 23(1): 2 (13 pages). doi: 10.1186/s12915-024-02105-7 (°IF 4.5)

  • Krug SM, Grünhagen C, Allers K, Bojarski C, Seybold J, Schneider T, Schulzke JD, Epple HJ (2023) Macromolecule translocation across the intestinal mucosa of HIV-infected patients by transcytosis and through apoptotic leaks. Cells 12(14): 1887 (13 pages). doi: 10.3390/cells12141887 (IF 5.1)

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 IF = Journal Impact factor of the respective publication year
°IF = Journal Impact factor for 2020, ad interim applied for 2021 papers
"accepted for publication": editotial acceptance e-mail at hand
#: Paper is authored by doctoral students of different projects, thus appearing more than once in the list

  
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