DFG Research Training Group "TJ-Train", GRK 2318

That's all about:

Very briefly: The tight junction (TJ) connects neighbouring epithelial or endothelial cells and is the central element of barrier function, as it controls paracellular passage of solutes and water. Whether the TJ simply increases tightness or selectively mediates permeability varies greatly in different tissues and is determined by the TJ protein composition. TJs underlie extensive extra- and intracellular signalling, but also regulate epithelial functions and cellular differentiation. Furthermore, numerous TJ proteins serve as receptors for certain pathogens. Thus, TJ proteins are involved in the pathogenesis of numerous diseases. Alterations in TJ composition and architecture may e.g. cause unwanted leak flux or antigen passage and may thus maintain disease activity or even directly trigger disease onset.

   

Names and projects A1 to C4  

     A:  Tight junction molecules, structure and function

Dorothee Günzel¹*, Jörg Scheffel^2
1Clinical Physiology / Nutritional Medicine, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
²Department of Dermatology, Venerology and Allergology, Charité - Universitätsmedizin Berlin
"Impedance analysis of epithelial barrier properties"
PhD doctoral student, 3^rd cohort: Evgeniya Kochina
PhD doctoral student, 2^nd cohort: Saeed Khomeijani Farahani
MD doctoral student, 2^nd cohort: Selma Dib
MD doctoral student, 2^nd cohort: Denisa Daci
PhD doctoral student, 1^st cohort: Roman Mannweiler
MD doctoral student, 1^st cohort: Ahmad Mouna

A2

Jörg Piontek¹*, Daniel Roderer^2
1Clinical Physiology / Nutritional Medicine, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
²Structural Bioinformatics & Protein Design, Leibniz Research Institute of Molecular Pharmacology (FMP), Berlin-Buch
"Structure-based modification of Clostridium perfringens enterotoxin to target claudins"
PhD doctoral student, 3^rd cohort: Joy Weber
PhD doctoral student, 2^nd cohort: Ayk Waldow
PhD doctoral student, 1^st cohort: Laura-Sophie Beier

A3

Michael Fromm*, JörgPiontek*
Clinical Physiology / Nutritional Medicine, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
"Claudin- and TAMP-mediated water transport"
PhD doctoral student, 3^rd cohort: Alina Handreg
PhD doctoral student, 2^nd cohort: Fabián Martínez-Perafán
PhD doctoral student, 1^st cohort: Carlos Ayala-Torres

A4

Martin Lehmann, Volker Haucke*
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin-Buch
"Dynamic super-resolution imaging of tight junction components, lipids and Ions"
PhD doctoral student, 3^rd cohort: Roman Shobik
PhD doctoral student, 2^nd cohort: Rozemarijn van der Veen
PhD doctoral student, 1^st cohort: Hannes Gonschior

     B:  Tight junction development and regulation

B1

Thomas Willnow*, Annette Hammes
Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin-Buch
"The endocytic receptor LRP2 serves as a central hub for dynamic cellular remodelling in neuronal stem cells and neural crest cells in the developing neural tube"
PhD doctoral student, 3^rd cohort: Alessia Petrella
PhD doctoral student, 2^nd cohort: Sher Min Mak
PhD doctoral student, 1^st cohort: Izabela Kowalczyk

B2

Michael Schumann¹*, Michael Hummel^2
1Medizinische Klinik m.S. Gastroenterologie, Infektiologie & Rheumatologie, Charité, CBF
²Molecularpathology Section at the Institute of Pathology, Charité, CCM
"Loss of epithelial polarity as a mechanism in inflammation-induced carcinogenesis"
PhD doctoral student, 3^rd cohort: Xuyue Liu
PhD doctoral student, 2^nd cohort: Subhakankha (Victor) Manna
PhD doctoral student, 1^st cohort: Danielle Cardoso-Silva

B3

Dominik Müller*, Tilman Breiderhoff
Klinik für Pädiatrie m.S. Nephrologie, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum
"The magnesiome, an integrative view of magnesium regulation"
PhD doctoral student, 3^rd cohort: Marah Alhabahbeh
PhD doctoral student, 2^nd cohort: Amr Al-Shebel
MD doctoral student, 2^nd cohort: Laura Kröhn
PhD doctoral student, 1^st cohort: Murat Seker

B4

Kai Schmidt-Ott¹*, Dorothee Günzel²*
¹Department of Nephrology and Hypertension, Medizinische Hochschule Hannover

²Clinical Physiology / Nutritional Medicine, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
"Transcriptional integration of tight junction biogenesis in kidney"
PhD doctoral student, 3^rd cohort: Arnold Tsamo
PhD doctoral student, 2^nd cohort: Shuang Cao
PhD doctoral student, 1^st cohort: Janna Leiz
MD doctoral student, 1^st cohort: Alexander Holler

     C:  Tight junction modulation in disease

C1

Jörg-Dieter Schulzke*, Roland Bücker
¹Clinical Physiology / Nutritional Medicine, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
"Toxin effects on paracellular intestinal barrier functions"
PhD doctoral student, 3^rd cohort: Jana Krause
PhD doctoral student, 2^nd cohort: Martina Schneemann
MD doctoral student, 2^nd cohort: Jan-Leo Kaak
MD doctoral student, 2^nd cohort: Helena Hader
PhD doctoral student, 1^st cohort: Praveen Kumar Nattramilarasu
MD doctoral student, 1^st cohort: Karem Awad
MD doctoral student, 1^st cohort: Lucas Heils
MD doctoral student, 1^st cohort: Sholpan Omarova
MD doctoral student, 1^st cohort: Eduard Butkevych

C2

Susanne Krug*
Clinical Physiology / Nutritional Medicine, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
"Interaction of immune cells and TJ proteins in inflammatory bowel diseases (IBD)"
PhD doctoral student, 3^rd cohort: Amélie Moll
MD doctoral student, 3^rd cohort: Madeleine Spahmann
PhD doctoral student, 2^nd cohort: Lena Voges
MD doctoral student, 2^nd cohort: Seymanur Yildirim
PhD doctoral student, 1^st cohort: Jia-Chen E. Hu

C3

Michael Schumann*, Britta Siegmund*
Medizinische Klinik m.S. Gastroenterologie, Infektiologie & Rheumatologie, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
"Polarity of microbiota-exposed intestinal epithelia and its
relevance for the induction of celiac disease"
PhD doctoral student, 3^rd cohort: Zitong Jiang
PhD doctoral student, 2^nd cohort: Violaine Dony
PhD doctoral student, 1^st cohort: Deborah Delbue
MD doctoral student, 1^st cohort: Daphni Siampli

C4

Nina Hering¹, Hans-Jörg Epple²*
¹Klinik für Allgemein- und Viszeralchirurgie, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
²Charité Outpatient Health Center, Infectiology and Hepatology
"The role of glucagon-like peptide-2 for macromolecule uptake and
immune activation in HIV enteropathy"
PhD doctoral student, 3^rd cohort: Alain Massarani
PhD doctoral student, 2^nd cohort: Valerie Masete
PhD doctoral student, 1^st cohort: Carolin Grünhagen
MD doctoral student, 1^st cohort: Hannah Lutz

Impressum